What if one of the most important molecules for producing energy in our bodies was also one of the least known?
It is called NAD+ and is present in practically all our cells. In recent years, it has sparked enormous interest due to its relationship with energy metabolism and processes associated with aging.
But supplements that promise to increase its levels have also appeared. And here arises an important question: does increasing NAD+ mean having more energy or aging better?
The answer is more interesting and quite a bit less straightforward than it seems.
What is NAD+ and what is it used for?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that participates in numerous chemical reactions essential to our bodies.
One of its main functions is to participate in the processes that allow the nutrients from food to be transformed into energy usable by the cells.
That energy is stored mainly in the form of ATP, a molecule necessary for our muscles, organs, and tissues to function.
But NAD+ is not limited to energy metabolism.
It also participates in processes related to the activity of certain enzymes, the response to DNA damage, and the regulation of cellular functions.
In other words, we are talking about a molecule that is fundamental to life, not an ingredient that our body has recently discovered thanks to dietary supplements.
NAD+ and NADH: what is the difference?
Although their names are almost identical, they represent two different forms of the same coenzyme.
The NAD+ is the oxidized form, capable of accepting electrons during certain metabolic reactions.
When it receives them, it transforms into NADH, its reduced form.
NADH can donate those electrons in other reactions, including those involved in the production of ATP in the mitochondria.
We can think of it as a transport system: one form collects electrons and the other delivers them.
The important thing is that both work together. It is not a matter of deciding which is better, but of understanding that this exchange is essential for cellular function.
What is the relationship between NAD+ and aging?
This is where one of the most interesting areas of research begins.
Various studies have linked changes in NAD+ metabolism to aging and certain diseases.
Promising results have been observed in animal models when increasing its levels.
However, data in humans are much more limited.
A review published in Nature Metabolism in 2025 indicates that the age-related decline in NAD+ has not been consistently demonstrated in all human tissues studied.
Therefore, we cannot yet state that increasing its levels through supplements delays aging or prolongs life.
Understanding the mechanisms of aging is one thing, and having found a way to stop them is quite another.
Do NAD+ supplements work?
Different ones exist, but they do not all contain the same substance.
Some provide precursors, that is, compounds that our body can use to make NAD+.
Among them are:
- Niacin (vitamin B3): participates in the natural pathways of NAD+ production.
- Nicotinamide riboside (NR): a precursor studied in clinical trials.
- Nicotinamide mononucleotide (NMN): another precursor under investigation, whose regulatory status must be checked before it is marketed.
- NADH: the reduced form of the coenzyme, also present in some supplements.
Clinical trials show that certain precursors, especially NR, can increase the concentrations of NAD+ measured in the blood.
However, increasing a biological marker does not automatically demonstrate a health benefit.
For now, there is not enough clinical evidence to generally recommend these supplements as a treatment for fatigue, to improve physical performance, or to achieve anti-aging effects.
How to choose a supplement related to NAD+?
Before buying, there are four aspects worth checking:
- The ingredient: check if it contains NADH, NR, niacin, or another substance.
- The amount per serving: not all products provide the same concentration.
- The complete composition: some formulas incorporate vitamins, minerals, or other ingredients.
- Safety and regulatory status: especially important in products with new ingredients or high concentrations.
There is no universal dose of NAD+ supplements proven to achieve anti-aging benefits.
If you take medication, have any medical conditions, or are pregnant or breastfeeding, consult a healthcare professional first.
NAD+-Related Supplements at Farmàcia Pasteur
At our pharmacy, you can find different formulas with nicotinamide riboside.
Tru Niagen 300 mg contains Niagen®, an NAD+ precursor studied in clinical trials.
NAD+ Cell Formula 100 mg offers another concentration of nicotinamide riboside.
Tru Niagen Immune 100 mg combines this precursor with vitamins and minerals.
They are different formulas, but none guarantees increased longevity or replaces healthy habits.
So, is supplementation worth it?
NAD+ is essential for our cells, and its metabolism represents a promising area of research.
But there is still much to discover about the real benefits of increasing its levels through supplements.
In the meantime, maintaining a balanced diet, exercising regularly, and getting adequate rest remain fundamental measures for taking care of our health.
At Farmàcia Pasteur, we help you understand the different options and choose based on information, not promises.
